FERMT2 Antibody (PACO58420)
- SKU:
- PACO58420
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FERMT2 Antibody (PACO58420) |
抗体コード: | PACO58420 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:500-1:1000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Fermitin family homolog 2 protein (155-232AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO58420 diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
![]() | Immunofluorescence staining of Hela cells with PACO58420 at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | IHC image of PACO58420 diluted at 1:500 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. |
シノニム: | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1), FERMT2, KIND2 MIG2 PLEKHC1 |
UniProt Protein Function: | kindlin-2: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. Belongs to the kindlin family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 14q22.1 Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; nucleoplasm; nucleus Molecular Function:phosphatidylinositol-3,4,5-triphosphate binding; protein binding Biological Process: cell-matrix adhesion; focal adhesion formation; integrin activation; integrin-mediated signaling pathway; transforming growth factor beta receptor signaling pathway; Wnt receptor signaling pathway |
UniProt Code: | Q96AC1 |
NCBI GenInfo Identifier: | 38258220 |
NCBI Gene ID: | 10979 |
NCBI Accession: | Q96AC1.1 |
UniProt Secondary Accession: | Q96AC1,Q14840, Q86TY7, B5TJY2, |
UniProt Related Accession: | Q96AC1 |
Molecular Weight: | 78,675 Da |
NCBI Full Name: | Fermitin family homolog 2 |
NCBI Synonym Full Names: | fermitin family member 2 |
NCBI Official Symbol: | FERMT2 |
NCBI Official Synonym Symbols: | MIG2; KIND2; mig-2; UNC112; PLEKHC1; UNC112B |
NCBI Protein Information: | fermitin family homolog 2 |
UniProt Protein Name: | Fermitin family homolog 2 |
UniProt Synonym Protein Names: | Kindlin-2; Mitogen-inducible gene 2 protein; MIG-2; Pleckstrin homology domain-containing family C member 1; PH domain-containing family C member 1 |
Protein Family: | Fermitin family |
UniProt Gene Name: | FERMT2 |
UniProt Entry Name: | FERM2_HUMAN |
Antibodies | ELISA Kits |
Anti-FERMT2 Antibody (CAB8709) | Human Fermitin family homolog 2 (FERMT2) ELISA Kit |
FERMT2 Antibody (PACO09276) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |