UniProt Protein Function: | FBXL2: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication. |
UniProt Protein Details: | Protein type:Ubiquitin ligase Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; membrane; SCF ubiquitin ligase complex Molecular Function:protein binding; protein phosphatase binding; ubiquitin-protein ligase activity Biological Process: protein modification process; protein ubiquitination; proteolysis; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UKC9 |
NCBI GenInfo Identifier: | 145559475 |
NCBI Gene ID: | 25827 |
NCBI Accession: | Q9UKC9.3 |
UniProt Secondary Accession: | Q9UKC9,Q6IAN3, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9, B4DQV0 E9PD06, |
UniProt Related Accession: | Q9UKC9 |
Molecular Weight: | 47kDa |
NCBI Full Name: | F-box/LRR-repeat protein 2 |
NCBI Synonym Full Names: | F-box and leucine rich repeat protein 2 |
NCBI Official Symbol: | FBXL2 |
NCBI Official Synonym Symbols: | FBL2; FBL3 |
NCBI Protein Information: | F-box/LRR-repeat protein 2 |
UniProt Protein Name: | F-box/LRR-repeat protein 2 |
UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 2 |
Protein Family: | F-box/LRR-repeat protein |
UniProt Gene Name: | FBXL2 |