FBXL2 Antibody, HRP conjugated (PACO42475)
- SKU:
- PACO42475
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | FBXL2 Antibody, HRP conjugated (PACO42475) |
抗体コード: | PACO42475 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy. PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (By similarity). |
シノニム: | F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3), FBXL2, FBL2 FBL3 |
UniProt Protein Function: | FBXL2: Calcium-activated substrate recognition component of a SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 doesn't seem to target phosphodegron within its substrates but rather calmodulin-binding motifs. Targets PCYT1A for its monoubiquitination and degradation, this is antagonized by calmodulin. Targets the cyclins CCND2 and CCND3 for polyubiquitination and degradation, leading to cell-cycle arrest in G(0), also antagonized by calmodulin. Binds to hepatitis C virus non-structural protein 5A (NS5A) in a reaction crucial for hepatitis C virus RNA replication. |
UniProt Protein Details: | Protein type:Ubiquitin ligase Chromosomal Location of Human Ortholog: 3p22.3 Cellular Component: cytoplasm; membrane; SCF ubiquitin ligase complex Molecular Function:protein binding; protein phosphatase binding; ubiquitin-protein ligase activity Biological Process: protein modification process; protein ubiquitination; proteolysis; regulation of autophagy; regulation of phosphoinositide 3-kinase cascade; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q9UKC9 |
NCBI GenInfo Identifier: | 145559475 |
NCBI Gene ID: | 25827 |
NCBI Accession: | Q9UKC9.3 |
UniProt Secondary Accession: | Q9UKC9,Q6IAN3, Q9NVQ8, Q9UK27, Q9UKA5, Q9Y3Y9, B4DQV0 E9PD06, |
UniProt Related Accession: | Q9UKC9 |
Molecular Weight: | 47kDa |
NCBI Full Name: | F-box/LRR-repeat protein 2 |
NCBI Synonym Full Names: | F-box and leucine rich repeat protein 2 |
NCBI Official Symbol: | FBXL2 |
NCBI Official Synonym Symbols: | FBL2; FBL3 |
NCBI Protein Information: | F-box/LRR-repeat protein 2 |
UniProt Protein Name: | F-box/LRR-repeat protein 2 |
UniProt Synonym Protein Names: | F-box and leucine-rich repeat protein 2 |
Protein Family: | F-box/LRR-repeat protein |
UniProt Gene Name: | FBXL2 |