FBP2 Antibody (PACO16328)
- SKU:
- PACO16328
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | FBP2 Antibody (PACO16328) |
抗体コード: | PACO16328 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Fusion protein of human FBP2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16328(FBP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16328(FBP2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. |
シノニム: | fructose-1,6-bisphosphatase 2 |
UniProt Protein Function: | FBPase 2: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans: FBP1 is expressed in the liver and gluconeogenic tissues, and FBP2 in striated muscle. FBP2 is only isozyme expressed in striated muscle and it is widely expressed in cells that are nongluconeogenic. Both forms are inhibited allosterically by AMP, NAD and Ca2+. The muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+, the major activator of glycolysis in striated muscle. Forms an active complex with aldolase that binds to the sarcomeric Z-line, which is disrupted by elevated calcium levels, blocking glycogen synthesis during exercise. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Its interaction with aldolase appears to desensitizes it to inhibition by AMP and, partially, by Ca2+. Up to 50% of lactate generated in striated muscle is converted to glycogen. |
UniProt Protein Details: | Protein type:EC 3.1.3.11; Carbohydrate Metabolism - pentose phosphate pathway; Phosphatase (non-protein); Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: cytosol Molecular Function:fructose-bisphosphatase activity; protein binding Biological Process: fructose metabolic process; gluconeogenesis |
NCBI Summary: | This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00757 |
NCBI GenInfo Identifier: | 76789651 |
NCBI Gene ID: | 8789 |
NCBI Accession: | O00757.2 |
UniProt Secondary Accession: | O00757,Q17R39, Q6FI53, |
UniProt Related Accession: | O00757 |
Molecular Weight: | 36,743 Da |
NCBI Full Name: | Fructose-1,6-bisphosphatase isozyme 2 |
NCBI Synonym Full Names: | fructose-bisphosphatase 2 |
NCBI Official Symbol: | FBP2 |
NCBI Protein Information: | fructose-1,6-bisphosphatase isozyme 2 |
UniProt Protein Name: | Fructose-1,6-bisphosphatase isozyme 2 |
UniProt Synonym Protein Names: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; Muscle FBPase |
Protein Family: | Fat body protein |
UniProt Gene Name: | FBP2 |
UniProt Entry Name: | F16P2_HUMAN |