FANCL Antibody, FITC conjugated (PACO57530)
- SKU:
- PACO57530
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | FANCL Antibody, FITC conjugated (PACO57530) |
抗体コード: | PACO57530 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase FANCL protein (138-248AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. |
シノニム: | E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL), FANCL, PHF9 |
UniProt Protein Function: | FANCL: Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth. Defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.-; Ubiquitin conjugating system; EC 6.3.2.19; Ligase Chromosomal Location of Human Ortholog: 2p16.1 Cellular Component: nucleoplasm; cytoplasm; nuclear envelope Molecular Function:zinc ion binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ligase activity Biological Process: protein monoubiquitination; gamete generation; DNA repair; response to DNA damage stimulus; regulation of cell proliferation Disease: Fanconi Anemia, Complementation Group L; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NW38 |
NCBI GenInfo Identifier: | 116241360 |
NCBI Gene ID: | 55120 |
NCBI Accession: | Q9NW38.2 |
UniProt Secondary Accession: | Q9NW38,Q6GU60, |
UniProt Related Accession: | Q9NW38 |
Molecular Weight: | 375 |
NCBI Full Name: | E3 ubiquitin-protein ligase FANCL |
NCBI Synonym Full Names: | Fanconi anemia, complementation group L |
NCBI Official Symbol: | FANCL |
NCBI Official Synonym Symbols: | POG; PHF9; FAAP43 |
NCBI Protein Information: | E3 ubiquitin-protein ligase FANCL; PHD finger protein 9; fanconi anemia group L protein; fanconi anemia-associated polypeptide of 43 kDa |
UniProt Protein Name: | E3 ubiquitin-protein ligase FANCL |
UniProt Synonym Protein Names: | Fanconi anemia group L protein; Fanconi anemia-associated polypeptide of 43 kDa; FAAP43 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | FANCL |
UniProt Entry Name: | FANCL_HUMAN |