FANCC Antibody, FITC conjugated (PACO26683)
- SKU:
- PACO26683
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | FANCC Antibody, FITC conjugated (PACO26683) |
抗体コード: | PACO26683 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Fanconi anemia group C protein (1-210AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. |
シノニム: | Fanconi anemia group C protein (Protein FACC), FANCC, FAC FACC |
UniProt Protein Function: | FANCC: DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC). A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 9q22.3 Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol Molecular Function:protein binding Biological Process: removal of superoxide radicals; nucleotide-excision repair; myeloid cell homeostasis; protein complex assembly; DNA repair; germ cell development Disease: Fanconi Anemia, Complementation Group C; Tracheoesophageal Fistula With Or Without Esophageal Atresia |
NCBI Summary: | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q00597 |
NCBI GenInfo Identifier: | 1706762 |
NCBI Gene ID: | 2176 |
NCBI Accession: | Q00597.1 |
UniProt Secondary Accession: | Q00597,B1ALR8, |
UniProt Related Accession: | Q00597 |
Molecular Weight: | 558 |
NCBI Full Name: | Fanconi anemia group C protein |
NCBI Synonym Full Names: | Fanconi anemia, complementation group C |
NCBI Official Symbol: | FANCC |
NCBI Official Synonym Symbols: | FA3; FAC; FACC |
NCBI Protein Information: | Fanconi anemia group C protein |
UniProt Protein Name: | Fanconi anemia group C protein |
Protein Family: | Fanconi anemia group C protein |
UniProt Gene Name: | FANCC |
UniProt Entry Name: | FANCC_HUMAN |