UniProt Protein Function: | EZH1: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Belongs to the histone-lysine methyltransferase family. EZ subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Methyltransferase; EC 2.1.1.43; Methyltransferase, protein lysine Chromosomal Location of Human Ortholog: 17q21.1-q21.3 Cellular Component: nucleoplasm; ESC/E(Z) complex Molecular Function:chromatin binding; histone lysine N-methyltransferase activity (H3-K27 specific) Biological Process: anatomical structure morphogenesis; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter |
NCBI Summary: | EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009] |
UniProt Code: | Q92800 |
NCBI GenInfo Identifier: | 3334182 |
NCBI Gene ID: | 2145 |
NCBI Accession: | Q92800.2 |
UniProt Secondary Accession: | Q92800,O43287, Q14459, Q53XP3, A6NCH6, B4DIJ1, B4DIZ7 B4DSS2, B4E3R7, |
UniProt Related Accession: | Q92800 |
Molecular Weight: | 747 |
NCBI Full Name: | Histone-lysine N-methyltransferase EZH1 |
NCBI Synonym Full Names: | enhancer of zeste 1 polycomb repressive complex 2 subunit |
NCBI Official Symbol: | EZH1 |
NCBI Official Synonym Symbols: | KMT6B |
NCBI Protein Information: | histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1 |
UniProt Protein Name: | Histone-lysine N-methyltransferase EZH1 |
UniProt Synonym Protein Names: | ENX-2; Enhancer of zeste homolog 1 |
Protein Family: | Histone-lysine N-methyltransferase |
UniProt Gene Name: | EZH1 |
UniProt Entry Name: | EZH1_HUMAN |