EYA2 Antibody, Biotin conjugated (PACO26588)
- SKU:
- PACO26588
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | EYA2 Antibody, Biotin conjugated (PACO26588) |
抗体コード: | PACO26588 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Eyes absent homolog 2 protein (1-514AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1. |
シノニム: | Eyes absent homolog 2 (EC 3.1.3.48), EYA2, EAB1 |
UniProt Protein Function: | EYA2: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity. Belongs to the HAD-like hydrolase superfamily. EYA family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48; Apoptosis; Cell development/differentiation Chromosomal Location of Human Ortholog: 20q13.1 Cellular Component: nucleoplasm Molecular Function:magnesium ion binding; protein binding; protein tyrosine phosphatase activity Biological Process: histone dephosphorylation; mesodermal cell fate specification |
NCBI Summary: | This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009] |
UniProt Code: | O00167 |
NCBI GenInfo Identifier: | 20455483 |
NCBI Gene ID: | 2139 |
NCBI Accession: | O00167.2 |
UniProt Secondary Accession: | O00167,Q5JSW8, Q86U84, Q96CV6, Q96H97, Q99503, Q99812 Q9BWF6, Q9H4S3, Q9H4S9, Q9NPZ4, Q9UIX7, |
UniProt Related Accession: | O00167 |
Molecular Weight: | 50,533 Da |
NCBI Full Name: | Eyes absent homolog 2 |
NCBI Synonym Full Names: | EYA transcriptional coactivator and phosphatase 2 |
NCBI Official Symbol: | EYA2 |
NCBI Official Synonym Symbols: | EAB1 |
NCBI Protein Information: | eyes absent homolog 2 |
UniProt Protein Name: | Eyes absent homolog 2 |
Protein Family: | Eyes absent |
UniProt Gene Name: | EYA2 |
UniProt Entry Name: | EYA2_HUMAN |