EXTL3 Antibody, HRP conjugated (PACO31613)
- SKU:
- PACO31613
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | EXTL3 Antibody, HRP conjugated (PACO31613) |
抗体コード: | PACO31613 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Exostosin-like 3 protein (2-245AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. |
シノニム: | Exostosin-like 3 (EC 2.4.1.223) (EXT-related protein 1) (Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase) (Hereditary multiple exostoses gene isolog) (Multiple exostosis-like protein 3) (Putative tumor suppressor protein EXTL3), EXTL3, EXTL1L EXTR1 KIAA0519 |
UniProt Protein Function: | EXTL3: Probable glycosyltransferase. Belongs to the glycosyltransferase 47 family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Transferase; EC 2.4.1.223; Glycan Metabolism - heparan sulfate biosynthesis Chromosomal Location of Human Ortholog: 8p21 Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane Molecular Function:metal ion binding; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity Biological Process: glycosaminoglycan biosynthetic process; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; unfolded protein response; heparan sulfate proteoglycan biosynthetic process; positive regulation of cell growth |
NCBI Summary: | This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012] |
UniProt Code: | O43909 |
NCBI GenInfo Identifier: | 6166159 |
NCBI Gene ID: | 2137 |
NCBI Accession: | O43909.1 |
UniProt Secondary Accession: | O43909,O00225, Q53XT3, D3DST8, |
UniProt Related Accession: | O43909 |
Molecular Weight: | Observed MW 105kDaCalculated MW 104kDa |
NCBI Full Name: | Exostosin-like 3 |
NCBI Synonym Full Names: | exostosin-like glycosyltransferase 3 |
NCBI Official Symbol: | EXTL3 |
NCBI Official Synonym Symbols: | RPR; BOTV; REGR; EXTR1; EXTL1L |
NCBI Protein Information: | exostosin-like 3; reg receptor; EXT-related 1; exostosin tumor-like 3; exostoses (multiple)-like 3; putative tumor suppressor protein EXTL3; hereditary multiple exostoses gene isolog; glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase |
UniProt Protein Name: | Exostosin-like 3 |
UniProt Synonym Protein Names: | EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3 |
Protein Family: | Exostosin |
UniProt Gene Name: | EXTL3 |
UniProt Entry Name: | EXTL3_HUMAN |