EXOSC5 Antibody, Biotin conjugated (PACO41393)
- SKU:
- PACO41393
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | EXOSC5 Antibody, Biotin conjugated (PACO41393) |
抗体コード: | PACO41393 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Exosome complex component RRP46 protein (1-235AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. |
シノニム: | Exosome complex component RRP46 (Chronic myelogenous leukemia tumor antigen 28) (Exosome component 5) (Ribosomal RNA-processing protein 46) (p12B), EXOSC5, CML28 RRP46 |
UniProt Protein Function: | EXOSC5: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. Belongs to the RNase PH family. |
UniProt Protein Details: | Protein type:Ribonuclease; Nucleolus; EC 3.1.13.- Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytoplasm; nucleolus; exosome (RNase complex); nucleus; cytosol Molecular Function:protein binding; 3'-5'-exoribonuclease activity; exoribonuclease activity; RNA binding Biological Process: gene expression; DNA deamination; defense response to virus; rRNA processing; mRNA catabolic process, deadenylation-dependent decay |
UniProt Code: | Q9NQT4 |
NCBI GenInfo Identifier: | 14285757 |
NCBI Gene ID: | 56915 |
NCBI Accession: | Q9NQT4.1 |
UniProt Related Accession: | Q9NQT4 |
Molecular Weight: | Calculated: 25kDaObserved: 25kDa |
NCBI Full Name: | Exosome complex component RRP46 |
NCBI Synonym Full Names: | exosome component 5 |
NCBI Official Symbol: | EXOSC5 |
NCBI Official Synonym Symbols: | p12B; RRP46; RRP41B; Rrp46p; hRrp46p |
NCBI Protein Information: | exosome complex component RRP46 |
UniProt Protein Name: | Exosome complex component RRP46 |
UniProt Synonym Protein Names: | Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B |
Protein Family: | Exosome complex component |
UniProt Gene Name: | EXOSC5 |
UniProt Entry Name: | EXOS5_HUMAN |