ESPN Antibody (PACO09146)
- SKU:
- PACO09146
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ESPN Antibody (PACO09146) |
抗体コード: | PACO09146 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human ESPN |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | espin;ESPN;DFNB36;DKFZp434A196;DKFZp434G2126 ; |
UniProt Protein Function: | ESPN: Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells. Defects in ESPN are the cause of deafness autosomal recessive type 36 with or without vestibular involvement (DFNB36). A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Actin-binding; Cytoskeletal Chromosomal Location of Human Ortholog: 1p36.31 Cellular Component: brush border; filamentous actin Molecular Function:actin filament binding; SH3 domain binding Disease: Deafness, Autosomal Recessive 36, With Or Without Vestibular Involvement |
NCBI Summary: | This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009] |
UniProt Code: | B1AK53 |
NCBI GenInfo Identifier: | 189037868 |
NCBI Gene ID: | 83715 |
NCBI Accession: | B1AK53.1 |
UniProt Secondary Accession: | B1AK53,Q6XYB2, Q9H0A2, Q9Y329, |
UniProt Related Accession: | B1AK53 |
Molecular Weight: | 31,636 Da |
NCBI Full Name: | Espin |
NCBI Synonym Full Names: | espin |
NCBI Official Symbol: | ESPN |
NCBI Official Synonym Symbols: | DFNB36; LP2654 |
NCBI Protein Information: | espin |
UniProt Protein Name: | Espin |
UniProt Synonym Protein Names: | Autosomal recessive deafness type 36 protein; Ectoplasmic specialization protein |
Protein Family: | Espin |
UniProt Gene Name: | ESPN |
UniProt Entry Name: | ESPN_HUMAN |