ERI1 Antibody (PACO06026)
- SKU:
- PACO06026
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ERI1 Antibody (PACO06026) |
抗体コード: | PACO06026 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:5000, WB:1:500-1:2000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthesized peptide derived from the Internal region of human ERI1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | ERI1; 3'EXO; THEX1; 3'-5' exoribonuclease 1; 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO |
UniProt Protein Function: | THEX1: RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs. Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs. Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. Although it can bind simultaneously with SLBP to the 3'-end of histone mRNA, the presence of SLBP prevents the exonuclease activity.Protein type: EC 3.1.-.-; Hydrolase; NucleolusChromosomal Location of Human Ortholog: 8p23.1Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: 3'-5' exonuclease activity; ribosome binding; rRNA bindingBiological Process: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA 3'-end processing |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q8IV48 |
NCBI GenInfo Identifier: | 45476938 |
NCBI Gene ID: | 90459 |
NCBI Accession: | Q8IV48.3 |
UniProt Secondary Accession: | Q8IV48,Q9NSX3, A8K4U7 |
UniProt Related Accession: | Q8IV48 |
Molecular Weight: | 40,064 Da |
NCBI Full Name: | 3'-5' exoribonuclease 1 |
NCBI Synonym Full Names: | exoribonuclease 1 |
NCBI Official Symbol: | ERI1 |
NCBI Official Synonym Symbols: | HEXO; THEX1; 3'HEXO |
NCBI Protein Information: | 3'-5' exoribonuclease 1 |
UniProt Protein Name: | 3'-5' exoribonuclease 1 |
UniProt Synonym Protein Names: | 3'-5' exonuclease ERI1; Eri-1 homolog; Histone mRNA 3'-end-specific exoribonuclease; Histone mRNA 3'-exonuclease 1; Protein 3'hExo; HEXO |
Protein Family: | ERI1 exoribonuclease |
UniProt Gene Name: | ERI1 |
UniProt Entry Name: | ERI1_HUMAN |