EPS8 Antibody, FITC conjugated (PACO55892)
- SKU:
- PACO55892
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | EPS8 Antibody, FITC conjugated (PACO55892) |
抗体コード: | PACO55892 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Epidermal growth factor receptor kinase substrate 8 protein (572-670AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. |
シノニム: | Epidermal growth factor receptor kinase substrate 8, EPS8 |
UniProt Protein Function: | EPS8: an adaptor protein that is an epidermal growth factor receptor (EGFR) substrate. Enhances EGF-dependent mitogenic signals. Member of a family of actin barbing and capping proteins. Promotes filopodial protrusions. Complexes containing Eps8/Abi1/PI3K/Sos-1 mediate Rac activation following EGFR signaling. Involved in endocytosis of EGFR by binding to the Rab5-specific GTPase activating protein USP6N. Binds to IRSp53, which binds small the small GTPases Rac and Cdc42, and which regulates actin dynamics. Involved in the actin-remodeling activity in cultured cerebellar neurons. Regulates the actin-remodeling activities of NMDA and ethanol in neurons. Eps8 knockout mice show behavioral resistance to ethanol. Expressed in all tissues analyzed, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in all epithelial and fibroblastic lines examined and in some, but not all, hematopoietic cells. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 12p12.3 Cellular Component: cell cortex; stereocilium; vesicle Molecular Function:actin binding; protein binding; Rac GTPase binding; SH3/SH2 adaptor activity Biological Process: actin crosslink formation; actin filament bundle formation; barbed-end actin filament capping; cell proliferation; epidermal growth factor receptor signaling pathway; exit from mitosis; Rac protein signal transduction; regulation of actin filament length; regulation of cell shape; signal transduction Disease: Deafness, Autosomal Recessive 102 |
NCBI Summary: | This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12929 |
NCBI GenInfo Identifier: | 2833239 |
NCBI Gene ID: | 2059 |
NCBI Accession: | Q12929.1 |
UniProt Secondary Accession: | Q12929,Q8N6J0, A6NMC3, A8K6W2, A8KA66, B4DX66, |
UniProt Related Accession: | Q12929 |
Molecular Weight: | 62,871 Da |
NCBI Full Name: | Epidermal growth factor receptor kinase substrate 8 |
NCBI Synonym Full Names: | epidermal growth factor receptor pathway substrate 8 |
NCBI Official Symbol: | EPS8 |
NCBI Official Synonym Symbols: | DFNB102 |
NCBI Protein Information: | epidermal growth factor receptor kinase substrate 8 |
UniProt Protein Name: | Epidermal growth factor receptor kinase substrate 8 |
Protein Family: | Epidermal growth factor receptor kinase substrate |
UniProt Gene Name: | EPS8 |
UniProt Entry Name: | EPS8_HUMAN |