UniProt Protein Function: | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. |
NCBI Summary: | This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012] |
UniProt Code: | O14682 |
NCBI GenInfo Identifier: | 12644050 |
NCBI Gene ID: | 8507 |
NCBI Accession: | O14682.2 |
UniProt Secondary Accession: | O14682,O75464, Q9UPG9, B4DHJ1, E9PFU0, |
UniProt Related Accession: | O14682 |
Molecular Weight: | 66kDa |
NCBI Full Name: | Ectoderm-neural cortex protein 1 |
NCBI Synonym Full Names: | ectodermal-neural cortex 1 |
NCBI Official Symbol: | ENC1 |
NCBI Official Synonym Symbols: | NRPB; CCL28; ENC-1; PIG10; KLHL35; KLHL37; TP53I10 |
NCBI Protein Information: | ectoderm-neural cortex protein 1 |
UniProt Protein Name: | Ectoderm-neural cortex protein 1 |
UniProt Synonym Protein Names: | Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein |
Protein Family: | Ectoderm-neural cortex protein |
UniProt Gene Name: | ENC1 |