EMP2 Antibody (PACO19598)
- SKU:
- PACO19598
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | EMP2 Antibody (PACO19598) |
抗体コード: | PACO19598 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human |
免疫原: | Synthetic peptide of human EMP2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19598(EMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO19598(EMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid, multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis. |
シノニム: | epithelial membrane protein 2 |
UniProt Protein Function: | EMP2: Belongs to the PMP-22/EMP/MP20 family. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 16p13.2 Cellular Component: apical part of cell; caveola; cell surface; cytoplasm; cytoplasmic vesicle; Golgi apparatus; lipid raft; nucleus; plasma membrane Molecular Function:integrin binding; kinase binding; protein binding; protein kinase binding Biological Process: actin filament organization; activation of protein kinase activity; bleb formation; blood vessel endothelial cell migration; cell adhesion; cell death; cell migration; cell proliferation; cell-matrix adhesion; early endosome to late endosome transport; embryo implantation; lipid raft formation; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; regulation of angiogenesis; regulation of glomerular filtration; regulation of kinase activity; T cell mediated cytotoxicity Disease: Nephrotic Syndrome, Type 10 |
NCBI Summary: | This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015] |
UniProt Code: | P54851 |
NCBI GenInfo Identifier: | 1706643 |
NCBI Gene ID: | 2013 |
NCBI Accession: | P54851.1 |
UniProt Secondary Accession: | P54851,B2R7V6, D3DUF8, |
UniProt Related Accession: | P54851 |
Molecular Weight: | 19,199 Da |
NCBI Full Name: | Epithelial membrane protein 2 |
NCBI Synonym Full Names: | epithelial membrane protein 2 |
NCBI Official Symbol: | EMP2 |
NCBI Official Synonym Symbols: | XMP |
NCBI Protein Information: | epithelial membrane protein 2 |
UniProt Protein Name: | Epithelial membrane protein 2 |
UniProt Synonym Protein Names: | Protein XMP |
Protein Family: | Epithelial membrane protein |
UniProt Gene Name: | EMP2 |
UniProt Entry Name: | EMP2_HUMAN |
Antibodies |
Anti-EMP2 Antibody (CAB16327) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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