EIF6 Antibody, FITC conjugated (PACO26439)
- SKU:
- PACO26439
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | EIF6 Antibody, FITC conjugated (PACO26439) |
抗体コード: | PACO26439 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Eukaryotic translation initiation factor 6 protein (1-245AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. |
シノニム: | Eukaryotic translation initiation factor 6 (eIF-6) (B(2)GCN homolog) (B4 integrin interactor) (CAB) (p27(BBP)), EIF6, EIF3A ITGB4BP |
UniProt Protein Function: | EIF6: eukaryotic translation initiation factor 6. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex. |
UniProt Protein Details: | Protein type:Translation; Translation initiation; Nucleolus Chromosomal Location of Human Ortholog: 20q12 Cellular Component: nucleoplasm; cytoplasm; nucleolus; lamin filament; nucleus Molecular Function:protein binding; translation initiation factor activity; ribosome binding; ribosomal large subunit binding Biological Process: translational initiation; ribosomal large subunit biogenesis and assembly; mature ribosome assembly; ribosome export from nucleus |
NCBI Summary: | Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple non-protein coding transcript variants and variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
UniProt Code: | P56537 |
NCBI GenInfo Identifier: | 3122258 |
NCBI Gene ID: | 3692 |
NCBI Accession: | P56537.1 |
UniProt Related Accession: | P56537 |
Molecular Weight: | |
NCBI Full Name: | Eukaryotic translation initiation factor 6 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 6 |
NCBI Official Symbol: | EIF6 |
NCBI Official Synonym Symbols: | CAB; EIF3A; eIF-6; p27BBP; ITGB4BP; b(2)gcn; p27(BBP) |
NCBI Protein Information: | eukaryotic translation initiation factor 6 |
UniProt Protein Name: | Eukaryotic translation initiation factor 6 |
UniProt Synonym Protein Names: | B(2)GCN homolog; B4 integrin interactor; CAB; p27(BBP) |
UniProt Gene Name: | EIF6 |
UniProt Entry Name: | IF6_HUMAN |