EIF4A2 Antibody, Biotin conjugated (PACO25363)
- SKU:
- PACO25363
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | EIF4A2 Antibody, Biotin conjugated (PACO25363) |
抗体コード: | PACO25363 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Eukaryotic initiation factor 4A-II protein (1-407AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Eukaryotic initiation factor 4A plays an important role in the binding of mRNA to the 43S preinitiation complex when protein synthesis begins. Two highly homologous forms of functional EIF4A genes, Eif4a1 and Eif4a2, have been isolated in mice; yeast cells also possess 2 EIF4A genes, TIF1 and TIF2. The murine Eif4a and yeast TIF genes appear to belong to a DEAD-box gene family, whose members exhibit extensive amino acid, similarity and contain the asp-glu-ala-asp (DEAD) sequence. DEAD-box genes have been identified in species ranging from E-coli to humans. Their function appears to be related to transcriptional/translational regulation (referenced from OMIM). |
シノニム: | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2), EIF4A2, DDX2B EIF4F |
UniProt Protein Function: | EIF4A2: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Belongs to the DEAD box helicase family. eIF4A subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.6.4.13; Helicase; RNA-binding; Translation; Translation initiation Chromosomal Location of Human Ortholog: 3q27.3 Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; perinuclear region of cytoplasm Molecular Function:ATP-dependent RNA helicase activity; ATPase activity; helicase activity; protein binding Biological Process: poly(A) tail shortening; RNA secondary structure unwinding; translational initiation |
UniProt Code: | Q14240 |
NCBI GenInfo Identifier: | 45645183 |
NCBI Gene ID: | 1974 |
NCBI Accession: | Q14240.2 |
UniProt Secondary Accession: | Q14240,Q53XJ6, Q96B90, Q96EA8, D3DNU9, |
UniProt Related Accession: | Q14240 |
Molecular Weight: | |
NCBI Full Name: | Eukaryotic initiation factor 4A-II |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 4A2 |
NCBI Official Symbol: | EIF4A2 |
NCBI Official Synonym Symbols: | DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II |
NCBI Protein Information: | eukaryotic initiation factor 4A-II |
UniProt Protein Name: | Eukaryotic initiation factor 4A-II |
UniProt Synonym Protein Names: | ATP-dependent RNA helicase eIF4A-2 |
Protein Family: | Eukaryotic initiation factor |
UniProt Gene Name: | EIF4A2 |