EIF2AK4 Antibody (PACO04352)
- SKU:
- PACO04352
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | EIF2AK4 Antibody |
抗体コード: | PACO04352 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | synthesized peptide derived from human GCN2 around the non-phosphorylation site of T899. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | EIF2AK4; GCN2; KIAA1338; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein |
UniProt Protein Function: | GCN2: a kinase of the PEK family. Phosphorylates and inhibits eukaryotic initiation factor (eIF)-2 alpha, providing an important protective mechanism during various cellular stress conditions including endoplasmic reticulum (ER) stress. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Translation; Other group; PEK family; GCN2 subfamily Chromosomal Location of Human Ortholog: 15q15.1 Molecular Function:protein serine/threonine kinase activity; eukaryotic translation initiation factor 2alpha kinase activity; ATP binding Biological Process: unfolded protein response; negative regulation of translation; cellular response to starvation; protein amino acid phosphorylation; regulation of translational initiation Disease: Pulmonary Venoocclusive Disease 2, Autosomal Recessive |
NCBI Summary: | This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2. [provided by RefSeq, Mar 2014] |
UniProt Code: | Q9P2K8 |
NCBI GenInfo Identifier: | 296439368 |
NCBI Gene ID: | 440275 |
NCBI Accession: | Q9P2K8.3 |
UniProt Secondary Accession: | Q9P2K8,Q69YL7, Q6DC97, Q96GN6, Q9H5K1, Q9NSQ3, Q9NSZ5 Q9UJ56, C9JEC4, |
UniProt Related Accession: | Q9P2K8 |
Molecular Weight: | |
NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 4 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 4 |
NCBI Official Symbol: | EIF2AK4 |
NCBI Official Synonym Symbols: | GCN2; PVOD2 |
NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein; GCN2 eIF2alpha kinase; general control nonderepressible 2 |
UniProt Protein Name: | Eukaryotic translation initiation factor 2-alpha kinase 4 |
UniProt Synonym Protein Names: | GCN2-like protein |
UniProt Gene Name: | EIF2AK4 |
UniProt Entry Name: | E2AK4_HUMAN |