EIF2AK3 Antibody, HRP conjugated (PACO62672)
- SKU:
- PACO62672
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | EIF2AK3 Antibody, HRP conjugated (PACO62672) |
抗体コード: | PACO62672 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Eukaryotic translation initiation factor 2-α kinase 3 protein (115-330AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Metabolic-stress sensing protein kinase that phosphorylates the α subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid, availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acid, , or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid, biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
シノニム: | Eukaryotic translation initiation factor 2-α kinase 3 (EC 2.7.11.1) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-α kinase) (HsPEK), EIF2AK3, PEK PERK |
NCBI Summary: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9NZJ5 |
NCBI GenInfo Identifier: | 296439367 |
NCBI Gene ID: | 9451 |
NCBI Accession: | |
UniProt Related Accession: | Q9NZJ5 |
Molecular Weight: | 170 |
NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 3 |
NCBI Official Symbol: | EIF2AK3 |
NCBI Official Synonym Symbols: | PEK; WRS; PERK |
NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 3 |
UniProt Protein Name: | |
UniProt Gene Name: |