EHD1 Antibody, HRP conjugated (PACO47183)
- SKU:
- PACO47183
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | EHD1 Antibody, HRP conjugated (PACO47183) |
抗体コード: | PACO47183 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human EH domain-containing protein 1 protein (401-498AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes. Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis. Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis. |
シノニム: | EH domain-containing protein 1 (PAST homolog 1) (hPAST1) (Testilin), EHD1, PAST PAST1 |
UniProt Protein Function: | EHD1: Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. |
UniProt Protein Details: | Protein type:Vesicle; Calcium-binding Chromosomal Location of Human Ortholog: 11q13 Cellular Component: early endosome membrane; endosome membrane; lipid particle; membrane; plasma membrane; recycling endosome membrane Molecular Function:ATP binding; calcium ion binding; GTP binding; protein binding; Rab GTPase binding Biological Process: blood coagulation; cholesterol homeostasis; cilium biogenesis; endocytic recycling; endocytosis; intracellular protein transport; neurite development; protein homooligomerization |
NCBI Summary: | This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] |
UniProt Code: | Q9H4M9 |
NCBI GenInfo Identifier: | 18202945 |
NCBI Gene ID: | 10938 |
NCBI Accession: | Q9H4M9.2 |
UniProt Secondary Accession: | Q9H4M9,O14611, Q2M3Q4, Q9UNR3, |
UniProt Related Accession: | Q9H4M9 |
Molecular Weight: | 60,627 Da |
NCBI Full Name: | EH domain-containing protein 1 |
NCBI Synonym Full Names: | EH domain containing 1 |
NCBI Official Symbol: | EHD1 |
NCBI Official Synonym Symbols: | PAST; PAST1; H-PAST; HPAST1 |
NCBI Protein Information: | EH domain-containing protein 1 |
UniProt Protein Name: | EH domain-containing protein 1 |
UniProt Synonym Protein Names: | PAST homolog 1 |
Protein Family: | EH domain-containing protein |
UniProt Gene Name: | EHD1 |
UniProt Entry Name: | EHD1_HUMAN |