EEF2K Antibody, FITC conjugated (PACO26395)
- SKU:
- PACO26395
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | EEF2K Antibody, FITC conjugated (PACO26395) |
抗体コード: | PACO26395 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Eukaryotic elongation factor 2 kinase protein (201-500AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. |
シノニム: | Eukaryotic elongation factor 2 kinase (eEF-2 kinase) (eEF-2K) (EC 2.7.11.20) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase), EEF2K |
UniProt Protein Function: | EEF2K: an atypical protein kinase of the Alpha family. Dependent on Ca2 ions and calmodulin. May play a key role linking cellular energy status and the inhibition of protein synthesis, a major consumer of metabolic energy. Phosphorylates and inactivates eEF2, resulting in the inhibition of peptide-chain elongation eEF2K is phosphorylated and activated by AMPK in response to elevated AMP levels, which increase during cellular stress and starvation. Regulated in response to a range of stimuli including TNF-alpha. Overexpressed in breast cancer cell lines and tumors. Activated in rat glioblastoma, and growth was inhibited by the drug Rottlerin. Activity induced in ischemic heart muscle |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Translation; Kinase, protein; Protein kinase, atypical; EC 2.7.11.20; ATYPICAL group; Alpha family; eEF2K subfamily Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: cytoplasm; cytosol Molecular Function:calmodulin binding; elongation factor-2 kinase activity; translation factor activity, nucleic acid binding; calcium ion binding; ATP binding; protein kinase activity Biological Process: translational elongation; regulation of protein amino acid autophosphorylation; protein amino acid autophosphorylation; insulin receptor signaling pathway |
NCBI Summary: | This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008] |
UniProt Code: | O00418 |
NCBI GenInfo Identifier: | 254763289 |
NCBI Gene ID: | 29904 |
NCBI Accession: | O00418.2 |
UniProt Secondary Accession: | O00418,Q8N588, |
UniProt Related Accession: | O00418 |
Molecular Weight: | 725 |
NCBI Full Name: | Eukaryotic elongation factor 2 kinase |
NCBI Synonym Full Names: | eukaryotic elongation factor 2 kinase |
NCBI Official Symbol: | EEF2K |
NCBI Official Synonym Symbols: | eEF-2K; HSU93850 |
NCBI Protein Information: | eukaryotic elongation factor 2 kinase; eEF-2 kinase; elongation factor-2 kinase; eukaroytic elongation factor 2 kinase; eukaryotic elongation factor-2 kinase; calmodulin-dependent protein kinase III; calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase; calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase |
UniProt Protein Name: | Eukaryotic elongation factor 2 kinase |
UniProt Synonym Protein Names: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase |
Protein Family: | Eukaryotic elongation factor 2 kinase |
UniProt Gene Name: | EEF2K |
UniProt Entry Name: | EF2K_HUMAN |