EEA1 Antibody (PACO21475)
- SKU:
- PACO21475
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | EEA1 Antibody (PACO21475) |
抗体コード: | PACO21475 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Peptide sequence around aa.12~16(R-V-G-S-Q)derived from Human EEA1. |
憲法: | Liquid |
ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extract from JK, HL-60 cells using EEA1 Antibody. |
バックグラウンド: | Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
シノニム: | MST105; ZFYVE2; MSTP105 |
UniProt Protein Function: | Function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. |
UniProt Protein Details: | Subunit structure: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding. Interacts with RAB31. Interacts with ERBB2. May interact with PLEKHF2. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.17 Ref.18 Subcellular location: Cytoplasm. Early endosome membrane; Peripheral membrane protein Ref.1 Ref.7 Ref.9 Ref.13 Ref.17. Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions. Ref.14 Miscellaneous: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Sequence similarities: Contains 1 C2H2-type zinc finger.Contains 1 FYVE-type zinc finger. |
UniProt Code: | Q15075 |
NCBI GenInfo Identifier: | 55770888 |
NCBI Gene ID: | 8411 |
NCBI Accession: | NP_003557.2 |
UniProt Secondary Accession: | Q15075,Q14221, |
UniProt Related Accession: | Q15075 |
Molecular Weight: | 162,466 Da |
NCBI Full Name: | early endosome antigen 1 |
NCBI Synonym Full Names: | early endosome antigen 1 |
NCBI Official Symbol: | EEA1 |
NCBI Official Synonym Symbols: | MST105; ZFYVE2; MSTP105 |
NCBI Protein Information: | early endosome antigen 1; early endosome antigen 1, 162kD; endosome-associated protein p162; early endosome-associated protein; zinc finger FYVE domain-containing protein 2 |
UniProt Protein Name: | Early endosome antigen 1 |
UniProt Synonym Protein Names: | Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2 |
Protein Family: | Early endosome antigen |
UniProt Gene Name: | EEA1 |
UniProt Entry Name: | EEA1_HUMAN |