EDNRB Antibody (PACO49542)
- SKU:
- PACO49542
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | EDNRB Antibody (PACO49542) |
抗体コード: | PACO49542 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Endothelin receptor type B protein (27-101AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Mouse heart tissue, Mouse skeletal muscle tissue. All lanes: EDNRB antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50, 49, 60 kDa. Observed band size: 50 kDa.. |
![]() | Immunofluorescent analysis of PC-3 cells using PACO49542 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human lung tissue using PACO49542 at dilution of 1:100. |
バックグラウンド: | Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
シノニム: | Endothelin receptor type B (ET-B) (ET-BR) (Endothelin receptor non-selective type), EDNRB, ETRB |
UniProt Protein Function: | ETB: a G protein-coupled receptor which activates a phosphatidylinoitol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutation in endothelin receptor type B gene. Essential component in the normal development of two neuronal crest-derived cell lineages. Two splice variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR Chromosomal Location of Human Ortholog: 13q22 Cellular Component: nuclear membrane; integral to plasma membrane; plasma membrane; lipid raft Molecular Function:endothelin receptor activity; protein binding; peptide hormone binding; type 1 angiotensin receptor binding Biological Process: epithelial fluid transport; cGMP-mediated signaling; regulation of fever; negative regulation of cellular protein metabolic process; response to pain; negative regulation of transcription from RNA polymerase II promoter; vein smooth muscle contraction; sensory perception of pain; response to organic cyclic substance; enteric nervous system development; vasodilation; regulation of epithelial cell proliferation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; regulation of blood pressure; melanocyte differentiation; positive regulation of cell proliferation; regulation of pH; neural crest cell migration; aging; posterior midgut development; nervous system development; vasoconstriction; negative regulation of adenylate cyclase activity; macrophage chemotaxis; peripheral nervous system development; negative regulation of neuron maturation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of protein amino acid phosphorylation; regulation of sensory perception of pain; negative regulation of apoptosis Disease: Waardenburg Syndrome, Type 4a; Abcd Syndrome; Hirschsprung Disease, Susceptibility To, 2 |
NCBI Summary: | The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
UniProt Code: | P24530 |
NCBI GenInfo Identifier: | 119622 |
NCBI Gene ID: | 1910 |
NCBI Accession: | P24530.1 |
UniProt Secondary Accession: | P24530,O15343, Q59GB1, Q5W0G9, Q8NHM6, Q8NHM7, Q8NHM8 Q8NHM9, Q9UD23, Q9UQK3, A2A2Z8, A8K3T4, |
UniProt Related Accession: | P24530,AAB24922 |
Molecular Weight: | 436 |
NCBI Full Name: | Endothelin B receptor |
NCBI Synonym Full Names: | endothelin receptor type B |
NCBI Official Symbol: | EDNRB |
NCBI Official Synonym Symbols: | ETB; ET-B; ETBR; ETRB; HSCR; WS4A; ABCDS; ET-BR; HSCR2 |
NCBI Protein Information: | endothelin B receptor; endothelin receptor non-selective type |
UniProt Protein Name: | Endothelin B receptor |
UniProt Synonym Protein Names: | Endothelin receptor non-selective type |
Protein Family: | Endothelin B receptor |
UniProt Gene Name: | EDNRB |
UniProt Entry Name: | EDNRB_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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