DUSP22 Antibody (PACO14386)
- SKU:
- PACO14386
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DUSP22 Antibody (PACO14386) |
抗体コード: | PACO14386 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human DUSP22 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14386(DUSP22 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes. |
シノニム: | dual specificity phosphatase 22 |
UniProt Protein Function: | DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity; EC 3.1.3.48; EC 3.1.3.16; Apoptosis Chromosomal Location of Human Ortholog: 6p25.3 Cellular Component: cytoplasm; nucleus Molecular Function:protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; inactivation of MAPK activity; regulation of cell proliferation |
UniProt Code: | Q9NRW4 |
NCBI GenInfo Identifier: | 74752929 |
NCBI Gene ID: | 56940 |
NCBI Accession: | Q9NRW4.1 |
UniProt Secondary Accession: | Q9NRW4,Q59GW2, Q5VWR2, Q96AR1, B4DK56, |
UniProt Related Accession: | Q9NRW4 |
Molecular Weight: | 184 |
NCBI Full Name: | Dual specificity protein phosphatase 22 |
NCBI Synonym Full Names: | dual specificity phosphatase 22 |
NCBI Official Symbol: | DUSP22 |
NCBI Official Synonym Symbols: | VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2 |
NCBI Protein Information: | dual specificity protein phosphatase 22; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2 |
UniProt Protein Name: | Dual specificity protein phosphatase 22 |
UniProt Synonym Protein Names: | JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x |
Protein Family: | Dual specificity protein phosphatase |
UniProt Gene Name: | DUSP22 |
UniProt Entry Name: | DUS22_HUMAN |