DTX3L Antibody (PACO08947)
- SKU:
- PACO08947
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DTX3L Antibody (PACO08947) |
抗体コード: | PACO08947 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human |
免疫原: | Human DTX3L |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | deltex 3-like (Drosophila);DTX3L;BBAP ; |
UniProt Protein Function: | DTX3L: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase Chromosomal Location of Human Ortholog: 3q21.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:histone binding; protein binding; ubiquitin-protein ligase activity Biological Process: double-strand break repair; histone monoubiquitination; protein polyubiquitination; response to DNA damage stimulus |
NCBI Summary: | DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009] |
UniProt Code: | Q8TDB6 |
NCBI GenInfo Identifier: | 37077418 |
NCBI Gene ID: | 151636 |
NCBI Accession: | Q8TDB6.1 |
UniProt Secondary Accession: | Q8TDB6,Q53ZZ3, Q5MJP7, B3KWH6, |
UniProt Related Accession: | Q8TDB6 |
Molecular Weight: | 25,792 Da |
NCBI Full Name: | E3 ubiquitin-protein ligase DTX3L |
NCBI Synonym Full Names: | deltex E3 ubiquitin ligase 3L |
NCBI Official Symbol: | DTX3L |
NCBI Official Synonym Symbols: | BBAP |
NCBI Protein Information: | E3 ubiquitin-protein ligase DTX3L |
UniProt Protein Name: | E3 ubiquitin-protein ligase DTX3L |
UniProt Synonym Protein Names: | B-lymphoma- and BAL-associated protein; Protein deltex-3-like; Rhysin-2; Rhysin2 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | DTX3L |
UniProt Entry Name: | DTX3L_HUMAN |