DSC1 Antibody (PACO19564)
- SKU:
- PACO19564
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DSC1 Antibody (PACO19564) |
抗体コード: | PACO19564 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Synthetic peptide of human DSC1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19564(DSC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19564(DSC1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. |
シノニム: | desmocollin 1 |
UniProt Protein Function: | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. |
NCBI Summary: | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015] |
UniProt Code: | Q08554 |
NCBI GenInfo Identifier: | 223590198 |
NCBI Gene ID: | 1823 |
NCBI Accession: | Q08554.2 |
UniProt Secondary Accession: | Q08554,Q9HB01, |
UniProt Related Accession: | Q08554 |
Molecular Weight: | 93,835 Da |
NCBI Full Name: | Desmocollin-1 |
NCBI Synonym Full Names: | desmocollin 1 |
NCBI Official Symbol: | DSC1 |
NCBI Official Synonym Symbols: | CDHF1; DG2/DG3 |
NCBI Protein Information: | desmocollin-1 |
UniProt Protein Name: | Desmocollin-1 |
UniProt Synonym Protein Names: | Cadherin family member 1; Desmosomal glycoprotein 2/3; DG2/DG3 |
Protein Family: | Desmocollin |
UniProt Gene Name: | DSC1 |
UniProt Entry Name: | DSC1_HUMAN |
Antibodies |
Anti-DSC1 Antibody (CAB10061) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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