DOK4 Antibody (PACO15673)
- SKU:
- PACO15673
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DOK4 Antibody (PACO15673) |
抗体コード: | PACO15673 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human DOK4 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15673(DOK4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO15673(DOK4 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Docking protein 4 is a protein that in humans is encoded by the DOK4 gene. Dok-4 is a 326 amino acid, protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis. |
シノニム: | docking protein 4 |
UniProt Protein Function: | DOK4: docking proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in Ret-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of Ret in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells. Interacts with Ret and TIE2. Interaction with Ret is mediated through the PTB domain and requires phosphorylation of Ret Y1062. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Cell development/differentiation Chromosomal Location of Human Ortholog: 16q21 Molecular Function:protein binding; receptor signaling protein activity; insulin receptor binding Biological Process: nervous system development; MAPKKK cascade; transmembrane receptor protein tyrosine kinase signaling pathway |
UniProt Code: | Q8TEW6 |
NCBI GenInfo Identifier: | 84029600 |
NCBI Gene ID: | 55715 |
NCBI Accession: | Q8TEW6.2 |
UniProt Secondary Accession: | Q8TEW6,O75209, Q9BTP2, Q9NVV3, |
UniProt Related Accession: | Q8TEW6 |
Molecular Weight: | 326 |
NCBI Full Name: | Docking protein 4 |
NCBI Synonym Full Names: | docking protein 4 |
NCBI Official Symbol: | DOK4 |
NCBI Protein Information: | docking protein 4; IRS5; IRS-5; insulin receptor substrate 5; downstream of tyrosine kinase 4 |
UniProt Protein Name: | Docking protein 4 |
UniProt Synonym Protein Names: | Downstream of tyrosine kinase 4; Insulin receptor substrate 5; IRS-5; IRS5 |
Protein Family: | Docking protein |
UniProt Gene Name: | DOK4 |
UniProt Entry Name: | DOK4_HUMAN |