DOCK2 Antibody (PACO03577)
- SKU:
- PACO03577
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | DOCK2 Antibody |
抗体コード: | PACO03577 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | IHC:1:100-1:300 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the Internal region of human DOCK 2. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | DOCK2; KIAA0209; Dedicator of cytokinesis protein 2 |
UniProt Protein Function: | DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho; Adaptor/scaffold Chromosomal Location of Human Ortholog: 5q35.1 Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol Molecular Function:protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding Biological Process: alpha-beta T cell proliferation; viral reproduction; formation of immunological synapse; myeloid dendritic cell activation during immune response; small GTPase mediated signal transduction; positive regulation of phagocytosis; establishment of T cell polarity; lipid raft polarization; chemotaxis; actin cytoskeleton organization and biogenesis; negative thymic T cell selection; regulation of defense response to virus by virus; positive thymic T cell selection Disease: Immunodeficiency 40 |
NCBI Summary: | The DOCK2 gene encodes a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis.[supplied by OMIM] |
UniProt Code: | Q92608 |
NCBI GenInfo Identifier: | 31377468 |
NCBI Gene ID: | 1794 |
NCBI Accession: | NP_004937.1 |
UniProt Secondary Accession: | Q92608,Q2M3I0, Q96AK7, |
UniProt Related Accession: | Q5XG91,Q6ZNS5,Q92608 |
Molecular Weight: | 211,948 Da |
NCBI Full Name: | dedicator of cytokinesis protein 2 |
NCBI Synonym Full Names: | dedicator of cytokinesis 2 |
NCBI Official Symbol: | DOCK2 |
NCBI Official Synonym Symbols: | FLJ46592; KIAA0209 |
NCBI Protein Information: | dedicator of cytokinesis protein 2; OTTHUMP00000160994; OTTHUMP00000223166; dedicator of cyto-kinesis 2 |
UniProt Protein Name: | Dedicator of cytokinesis protein 2 |
Protein Family: | Dedicator of cytokinesis protein |
UniProt Gene Name: | DOCK2 |
UniProt Entry Name: | DOCK2_HUMAN |