DNAJC10 Antibody, FITC conjugated (PACO63149)
- SKU:
- PACO63149
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | DNAJC10 Antibody, FITC conjugated (PACO63149) |
抗体コード: | PACO63149 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human DnaJ homolog subfamily C member 10 protein (521-793AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. |
シノニム: | DnaJ homolog subfamily C member 10 (EC 1.8.4) (Endoplasmic reticulum DNA J domain-containing protein 5) (ER-resident protein ERdj5) (ERdj5) (Macrothioredoxin) (MTHr), DNAJC10, ERDJ5 |
UniProt Protein Function: | DNAJC10: This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Chaperone; Endoplasmic reticulum; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q32.1 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; membrane Molecular Function:ATPase activator activity; ATPase binding; chaperone binding; disulfide oxidoreductase activity; Hsp70 protein binding; misfolded protein binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; protein binding; protein disulfide oxidoreductase activity Biological Process: ER-associated protein catabolic process; negative regulation of protein amino acid phosphorylation; positive regulation of ATPase activity |
NCBI Summary: | This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012] |
UniProt Code: | Q8IXB1 |
NCBI GenInfo Identifier: | 142981524 |
NCBI Gene ID: | 54431 |
NCBI Accession: | Q8IXB1.2 |
UniProt Secondary Accession: | Q8IXB1,Q17RJ6, Q3B7W8, Q4ZG06, Q53QT7, Q6UWZ6, Q86T61 Q8NC82, Q8TD87, Q96K38, Q96K44, Q96K54, |
UniProt Related Accession: | Q8IXB1 |
Molecular Weight: | 91kDa |
NCBI Full Name: | DnaJ homolog subfamily C member 10 |
NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member C10 |
NCBI Official Symbol: | DNAJC10 |
NCBI Official Synonym Symbols: | JPDI; MTHr; ERdj5; PDIA19 |
NCBI Protein Information: | dnaJ homolog subfamily C member 10 |
UniProt Protein Name: | DnaJ homolog subfamily C member 10 |
UniProt Synonym Protein Names: | Endoplasmic reticulum DNA J domain-containing protein 5; ER-resident protein ERdj5; ERdj5; Macrothioredoxin; MTHr |
Protein Family: | DnaJ homolog subfamily |
UniProt Gene Name: | DNAJC10 |