DLC1 Antibody (PACO03340)
- SKU:
- PACO03340
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | DLC1 Antibody |
抗体コード: | PACO03340 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | IHC:1:100-1:300, IF:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | synthesized peptide derived from the N-terminal region of human DLC-1. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | DLC1; ARHGAP7; KIAA1723; STARD12; Rho GTPase-activating protein 7; Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein |
UniProt Protein Function: | DLC1: Functions as a GTPase-activating protein specific for Rho and an activator of PLCD1 in vivo and induces morphological changes and detachment through cytoskeletal reorganization. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GAPs; GAPs, Rac/Rho; Tumor suppressor Chromosomal Location of Human Ortholog: 8p22 Cellular Component: cortical actin cytoskeleton; focal adhesion; cytoplasm; caveola; cytosol; nucleus Molecular Function:protein binding; SH2 domain binding; lipid binding Biological Process: caspase activation; focal adhesion formation; heart morphogenesis; hindbrain morphogenesis; negative regulation of stress fiber formation; apoptosis; negative regulation of focal adhesion formation; positive regulation of protein amino acid dephosphorylation; regulation of cell shape; negative regulation of cell proliferation; regulation of small GTPase mediated signal transduction; negative regulation of Rho protein signal transduction; small GTPase mediated signal transduction; regulation of actin cytoskeleton organization and biogenesis; neural tube closure; forebrain development; actin cytoskeleton organization and biogenesis; negative regulation of cell migration Disease: Colorectal Cancer |
NCBI Summary: | This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010] |
UniProt Code: | Q96QB1 |
NCBI GenInfo Identifier: | 313104315 |
NCBI Gene ID: | 10395 |
NCBI Accession: | Q96QB1.4 |
UniProt Secondary Accession: | Q96QB1,O14868, O43199, Q7Z5R8, Q86UC6, Q9C0E0, Q9H7A2 B4DR10, B8PTI0, E9PDZ8, E9PF76, E9PGY9, |
UniProt Related Accession: | Q96QB1 |
Molecular Weight: | 1528 |
NCBI Full Name: | Rho GTPase-activating protein 7 |
NCBI Synonym Full Names: | DLC1 Rho GTPase activating protein |
NCBI Official Symbol: | DLC1 |
NCBI Official Synonym Symbols: | HP; ARHGAP7; STARD12; p122-RhoGAP |
NCBI Protein Information: | rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; deleted in liver cancer 1 protein; START domain-containing protein 12; deleted in liver cancer 1 variant 2; rho-type GTPase-activating protein 7; StAR-related lipid transfer (START) domain containing 12 |
UniProt Protein Name: | Rho GTPase-activating protein 7 |
UniProt Synonym Protein Names: | Deleted in liver cancer 1 protein; DLC-1; HP protein; Rho-type GTPase-activating protein 7; START domain-containing protein 12; StARD12; StAR-related lipid transfer protein 12 |
Protein Family: | Dynein |
UniProt Gene Name: | DLC1 |
UniProt Entry Name: | RHG07_HUMAN |