DHH Antibody (PACO62267)
- SKU:
- PACO62267
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DHH Antibody (PACO62267) |
抗体コード: | PACO62267 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Desert hedgehog protein (51-158AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunofluorescence staining of A549 cells with PACO62267 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. |
シノニム: | Desert hedgehog protein (DHH) (HHG-3) [Cleaved into: Desert hedgehog protein N-product; Desert hedgehog protein C-product], DHH |
UniProt Protein Function: | DHH: Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development. Defects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD). PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity. Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM); also known as male- limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks. Belongs to the hedgehog family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Cell development/differentiation Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: extracellular space; plasma membrane Molecular Function:peptidase activity; protein binding; zinc ion binding; patched binding; calcium ion binding Biological Process: myelination; Leydig cell differentiation; cell-cell signaling; male sex determination; regulation of steroid biosynthetic process; proteolysis; spermatid development; response to estradiol stimulus Disease: 46,xy Gonadal Dysgenesis, Partial, With Minifascicular Neuropathy; 46,xy Sex Reversal 7 |
NCBI Summary: | This gene encodes a member of the hedgehog family. The hedgehog gene family encodes signaling molecules that play an important role in regulating morphogenesis. This protein is predicted to be made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the organism. Defects in this protein have been associated with partial gonadal dysgenesis (PGD) accompanied by minifascicular polyneuropathy. This protein may be involved in both male gonadal differentiation and perineurial development. [provided by RefSeq, May 2010] |
UniProt Code: | O43323 |
NCBI GenInfo Identifier: | 6166118 |
NCBI Gene ID: | 50846 |
NCBI Accession: | O43323.1 |
UniProt Secondary Accession: | O43323,Q15794, |
UniProt Related Accession: | O43323 |
Molecular Weight: | 43,577 Da |
NCBI Full Name: | Desert hedgehog protein |
NCBI Synonym Full Names: | desert hedgehog |
NCBI Official Symbol: | DHH |
NCBI Official Synonym Symbols: | GDXYM; HHG-3; SRXY7 |
NCBI Protein Information: | desert hedgehog protein; mutant desert hedgehog; desert hedgehog homolog |
UniProt Protein Name: | Desert hedgehog protein |
UniProt Synonym Protein Names: | HHG-3 |
Protein Family: | Desert hedgehog protein |
UniProt Gene Name: | DHH |
UniProt Entry Name: | DHH_HUMAN |
Antibodies | ELISA Kits |
Anti-DHH Antibody (CAB13177) | Human Desert Hedgehog / Dhh ELISA Kit |
Human Desert hedgehog protein (DHH) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |