DDX3Y Antibody (PACO05595)
- SKU:
- PACO05595
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DDX3Y Antibody (PACO05595) |
抗体コード: | PACO05595 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:20000, IHC:1:100-1:300 |
反応性: | Human, Mouse |
免疫原: | Synthesized peptide derived from the N-terminal region of human DDX3Y. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | DDX3Y; DBY; ATP-dependent RNA helicase DDX3Y; DEAD box protein 3; Y-chromosomal |
UniProt Protein Function: | DDX3Y: a Y-linked DEAD box protein. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp, are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. DBY mutations causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Two alternatively spliced transcripts differ only in the length of the 3' UTR. |
UniProt Protein Details: | Protein type:RNA-binding; EC 3.6.4.13; Helicase Chromosomal Location of Human Ortholog: Yq11 Cellular Component: cytoplasm; membrane Molecular Function:ATP-dependent RNA helicase activity Biological Process: chromosome segregation; regulation of gene expression; RNA secondary structure unwinding; translational initiation Disease: Spermatogenic Failure, Y-linked, 2 |
NCBI Summary: | The protein encoded by this gene is a member of the DEAD-box RNA helicase family, characterized by nine conserved motifs, included the conserved Asp-Glu-Ala-Asp (DEAD) motif. These motifs are thought to be involved in ATP binding, hydrolysis, RNA binding, and in the formation of intramolecular interactions. This protein shares high similarity to DDX3X, on the X chromosome, but a deletion of this gene is not complemented by DDX3X. Mutations in this gene result in male infertility, a reduction in germ cell numbers, and can result in Sertoli-cell only sydrome. Pseudogenes sharing similarity to both this gene and the DDX3X paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
UniProt Code: | O15523 |
NCBI GenInfo Identifier: | 73620957 |
NCBI Gene ID: | 8653 |
NCBI Accession: | O15523.2 |
UniProt Secondary Accession: | O15523,Q8IYV7, B4DK29, B4DXX7, |
UniProt Related Accession: | O15523 |
Molecular Weight: | 32,416 Da |
NCBI Full Name: | ATP-dependent RNA helicase DDX3Y |
NCBI Synonym Full Names: | DEAD-box helicase 3, Y-linked |
NCBI Official Symbol: | DDX3Y |
NCBI Official Synonym Symbols: | DBY |
NCBI Protein Information: | ATP-dependent RNA helicase DDX3Y |
UniProt Protein Name: | ATP-dependent RNA helicase DDX3Y |
UniProt Synonym Protein Names: | DEAD box protein 3, Y-chromosomal |
Protein Family: | ATP-dependent RNA helicase |
UniProt Gene Name: | DDX3Y |
UniProt Entry Name: | DDX3Y_HUMAN |