DCP2 Antibody, FITC conjugated (PACO37652)
- SKU:
- PACO37652
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | DCP2 Antibody, FITC conjugated (PACO37652) |
抗体コード: | PACO37652 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human m7GpppN-mRNA hydrolase protein (1-385AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. |
シノニム: | m7GpppN-mRNA hydrolase (EC 3.6.1.62) (Nucleoside diphosphate-linked moiety X motif 20) (Nudix motif 20) (mRNA-decapping enzyme 2) (hDpc), DCP2, NUDT20 |
UniProt Protein Function: | DCP2: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Removes the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking a RNA moiety. Belongs to the Nudix hydrolase family. DCP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.6.1.62; Hydrolase; RNA processing Chromosomal Location of Human Ortholog: 5q22.2 Cellular Component: cell junction; cytosol; intracellular membrane-bound organelle; nucleoplasm Molecular Function:exoribonuclease activity, producing 5'-phosphomonoesters; m7G(5')pppN diphosphatase activity; protein binding Biological Process: deadenylation-dependent decapping; mRNA catabolic process; mRNA catabolic process, nonsense-mediated decay; regulation of mRNA stability |
NCBI Summary: | The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011] |
UniProt Code: | Q8IU60 |
NCBI GenInfo Identifier: | 269849560 |
NCBI Gene ID: | 167227 |
NCBI Accession: | Q8IU60.2 |
UniProt Secondary Accession: | Q8IU60,Q6P2D4, Q7Z5W5, Q8NBG5, C9J778, |
UniProt Related Accession: | Q8IU60 |
Molecular Weight: | 44,443 Da |
NCBI Full Name: | m7GpppN-mRNA hydrolase |
NCBI Synonym Full Names: | decapping mRNA 2 |
NCBI Official Symbol: | DCP2 |
NCBI Official Synonym Symbols: | NUDT20 |
NCBI Protein Information: | m7GpppN-mRNA hydrolase |
UniProt Protein Name: | m7GpppN-mRNA hydrolase |
UniProt Synonym Protein Names: | Nucleoside diphosphate-linked moiety X motif 20; Nudix motif 20; mRNA-decapping enzyme 2; hDpc |
Protein Family: | mRNA-decapping enzyme |
UniProt Gene Name: | DCP2 |
UniProt Entry Name: | DCP2_HUMAN |