DCD Antibody (PACO26149)
- SKU:
- PACO26149
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | DCD Antibody (PACO26149) |
抗体コード: | PACO26149 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
反応性: | Human |
免疫原: | Recombinant Human Dermcidin protein (20-110AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | IHC image of PACO26149 diluted at 1:400 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
バックグラウンド: | DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG. |
シノニム: | Dermcidin (EC 3.4.-.-) (Preproteolysin) [Cleaved into: Survival-promoting peptide; DCD-1], DCD, AIDD DSEP |
UniProt Protein Function: | DCD: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; EC 3.4.-.-; Secreted Chromosomal Location of Human Ortholog: 12q13.1 Cellular Component: extracellular region Molecular Function:protein binding |
NCBI Summary: | This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014] |
UniProt Code: | P81605 |
NCBI GenInfo Identifier: | 20141302 |
NCBI Gene ID: | 117159 |
NCBI Accession: | P81605.2 |
UniProt Secondary Accession: | P81605,P58461, Q53YJ2, A5JHP2, A5JHP3, |
UniProt Related Accession: | P81605 |
Molecular Weight: | 8,295 Da |
NCBI Full Name: | Dermcidin |
NCBI Synonym Full Names: | dermcidin |
NCBI Official Symbol: | DCD |
NCBI Official Synonym Symbols: | PIF; AIDD; DSEP; HCAP; DCD-1 |
NCBI Protein Information: | dermcidin |
UniProt Protein Name: | Dermcidin |
UniProt Synonym Protein Names: | Preproteolysin |
Protein Family: | Dermcidin |
UniProt Gene Name: | DCD |
UniProt Entry Name: | DCD_HUMAN |
Antibodies | ELISA Kits |
Anti-DCD Antibody (CAB7280) | Human PIF/DCD(Proteolysis Inducing Factor/Dermcidin) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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