UniProt Protein Function: | DAOA: Seems to activate D-amino acid oxidase. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 13q33.2|13q34Cellular Component: Golgi apparatus; mitochondrion; perinuclear region of cytoplasmMolecular Function: enzyme activator activity; enzyme bindingBiological Process: positive regulation of catalytic activityDisease: Schizophrenia |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011] |
UniProt Code: | P59103 |
NCBI GenInfo Identifier: | 84028201 |
NCBI Gene ID: | 267012 |
NCBI Accession: | P59103.2 |
UniProt Secondary Accession: | P59103,Q0VAE6, Q5VX59, Q86Y17, Q8IWM4, A6NKG7 |
UniProt Related Accession: | P59103 |
Molecular Weight: | 14,719 Da |
NCBI Full Name: | D-amino acid oxidase activator |
NCBI Synonym Full Names: | D-amino acid oxidase activator |
NCBI Official Symbol: | DAOA |
NCBI Official Synonym Symbols: | LG72; SG72 |
NCBI Protein Information: | D-amino acid oxidase activator |
UniProt Protein Name: | D-amino acid oxidase activator |
UniProt Synonym Protein Names: | Protein G72 |
Protein Family: | D-amino acid oxidase activator |
UniProt Gene Name: | DAOA |
UniProt Entry Name: | DAOA_HUMAN |