CXCL11 Antibody (PACO47774)
- SKU:
- PACO47774
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CXCL11 Antibody (PACO47774) |
抗体コード: | PACO47774 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human C-X-C motif chemokine 11 protein (22-94AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human brain tissue using PACO47774 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO47774 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO47774 at dilution of 1:100. |
バックグラウンド: | Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. |
シノニム: | C-X-C motif chemokine 11 (Beta-R1) (H174) (Interferon gamma-inducible protein 9) (IP-9) (Interferon-inducible T-cell α chemoattractant) (I-TAC) (Small-inducible cytokine B11), CXCL11, ITAC SCYB11 SCYB9B |
UniProt Protein Function: | CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Chemokine; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q21.2 Cellular Component: extracellular space; extracellular region Molecular Function:heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; inflammatory response; regulation of cell proliferation |
NCBI Summary: | Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014] |
UniProt Code: | O14625 |
NCBI GenInfo Identifier: | 7674360 |
NCBI Gene ID: | 6373 |
NCBI Accession: | O14625.1 |
UniProt Related Accession: | O14625 |
Molecular Weight: | |
NCBI Full Name: | C-X-C motif chemokine 11 |
NCBI Synonym Full Names: | C-X-C motif chemokine ligand 11 |
NCBI Official Symbol: | CXCL11 |
NCBI Official Synonym Symbols: | IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B |
NCBI Protein Information: | C-X-C motif chemokine 11 |
UniProt Protein Name: | C-X-C motif chemokine 11 |
UniProt Synonym Protein Names: | Beta-R1; H174; Interferon gamma-inducible protein 9; IP-9; Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11 |
UniProt Gene Name: | CXCL11 |
UniProt Entry Name: | CXL11_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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