CXCL1 Antibody (PACO32100)
- SKU:
- PACO32100
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CXCL1 Antibody (PACO32100) |
抗体コード: | PACO32100 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Growth-regulated α protein (35-107AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. |
シノニム: | Growth-regulated α protein (C-X-C motif chemokine 1) (GRO-alpha(1-73)) (Melanoma growth stimulatory activity) (MGSA) (Neutrophil-activating protein 3) (NAP-3) [Cleaved into: GRO-alpha(4-73); GRO-alpha(5-73); GRO-alpha(6-73)], CXCL1, GRO GRO1 GROA MGSA SCYB1 |
UniProt Protein Function: | CXCL1: Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO- alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity. Belongs to the intercrine alpha (chemokine CxC) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular space; extracellular region Molecular Function:growth factor activity; chemokine activity; CXCR chemokine receptor binding; enzyme activator activity; receptor binding Biological Process: positive regulation of catalytic activity; G-protein coupled receptor protein signaling pathway; cell proliferation; nervous system development; negative regulation of cell proliferation; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; actin cytoskeleton organization and biogenesis; chemotaxis; signal transduction |
NCBI Summary: | This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014] |
UniProt Code: | P09341 |
NCBI GenInfo Identifier: | 121622 |
NCBI Gene ID: | 2919 |
NCBI Accession: | P09341.1 |
UniProt Secondary Accession: | P09341,Q9UCR7, |
UniProt Related Accession: | P09341 |
Molecular Weight: | |
NCBI Full Name: | Growth-regulated alpha protein |
NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
NCBI Official Symbol: | CXCL1 |
NCBI Official Synonym Symbols: | FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a |
NCBI Protein Information: | growth-regulated alpha protein; MGSA alpha; GRO-alpha(1-73); C-X-C motif chemokine 1; fibroblast secretory protein; neutrophil-activating protein 3; melanoma growth stimulatory activity alpha; GRO1 oncogene (melanoma growth-stimulating activity); GRO1 oncogene (melanoma growth stimulating activity, alpha) |
UniProt Protein Name: | Growth-regulated alpha protein |
UniProt Synonym Protein Names: | C-X-C motif chemokine 1; GRO-alpha(1-73); Melanoma growth stimulatory activity; MGSA; Neutrophil-activating protein 3; NAP-3 |
Protein Family: | Growth-regulated alpha protein |
UniProt Gene Name: | CXCL1 |
UniProt Entry Name: | GROA_HUMAN |