CX3CL1 Antibody (PACO17756)
- SKU:
- PACO17756
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | CX3CL1 Antibody (PACO17756) |
抗体コード: | PACO17756 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:10000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human CX3CL1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17756(CX3CL1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a large cytokine protein of 373 amino acid, , it contains multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice).The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines.CX3CL1 is produced as a long protein (with 373-amino acid, in humans) with an extended mucin-like stalk and a chemokine domain on top. The mucin-like stalk permits it to bind to the surface of certain cells. However a soluble (90 kD) version of this chemokine has also been observed. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound chemokine promotes strong adhesion of leukocytes to activated endothelial cells, where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1. Its gene is located on human chromosome 16 along with some CC chemokines known as CCL17 and CCL22. |
シノニム: | chemokine (C-X3-C motif) ligand 1 |
UniProt Protein Function: | CX3CL1: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. Belongs to the intercrine delta family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral Chromosomal Location of Human Ortholog: 16q13 Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane; extracellular region Molecular Function:protein binding; chemokine activity; receptor binding Biological Process: positive regulation of transforming growth factor-beta1 production; neutrophil chemotaxis; leukocyte chemotaxis; cytokine and chemokine mediated signaling pathway; defense response; chemotaxis; angiogenesis involved in wound healing; macrophage chemotaxis; leukocyte adhesive activation; positive regulation of angiogenesis; positive regulation of calcium-independent cell-cell adhesion; immune response; cell adhesion; lymphocyte chemotaxis; positive regulation of inflammatory response |
UniProt Code: | P78423 |
NCBI GenInfo Identifier: | 6175080 |
NCBI Gene ID: | 6376 |
NCBI Accession: | P78423.1 |
UniProt Secondary Accession: | P78423,O00672, |
UniProt Related Accession: | P78423 |
Molecular Weight: | 42,203 Da |
NCBI Full Name: | Fractalkine |
NCBI Synonym Full Names: | chemokine (C-X3-C motif) ligand 1 |
NCBI Official Symbol: | CX3CL1 |
NCBI Official Synonym Symbols: | NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin |
NCBI Protein Information: | fractalkine; C-X3-C motif chemokine 1; small-inducible cytokine D1; CX3C membrane-anchored chemokine; small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin) |
UniProt Protein Name: | Fractalkine |
UniProt Synonym Protein Names: | C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1Cleaved into the following chain:Processed fractalkine |
Protein Family: | Fractalkine |
UniProt Gene Name: | CX3CL1 |
UniProt Entry Name: | X3CL1_HUMAN |
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