CUX1 Antibody, FITC conjugated (PACO62257)
- SKU:
- PACO62257
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | CUX1 Antibody, FITC conjugated (PACO62257) |
抗体コード: | PACO62257 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Homeobox protein cut-like 1 protein (24-94AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) β enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR β enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator (By similarity). |
シノニム: | Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein cux-1), CUX1, CUTL1 |
UniProt Protein Function: | CUTL1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA-binding; Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to Golgi membrane; nucleus; cytosol Molecular Function:sequence-specific DNA binding; chromatin binding Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development |
NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
UniProt Code: | P39880 |
NCBI GenInfo Identifier: | 296439379 |
NCBI Gene ID: | 1523 |
NCBI Accession: | P39880.3 |
UniProt Secondary Accession: | P39880,Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5 B3KV79, J3KQV9, |
UniProt Related Accession: | P39880,Q13948 |
Molecular Weight: | 77 kDa |
NCBI Full Name: | Homeobox protein cut-like 1 |
NCBI Synonym Full Names: | cut-like homeobox 1 |
NCBI Official Symbol: | CUX1 |
NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 |
NCBI Protein Information: | protein CASP; cut homolog; homeobox protein cux-1; CCAAT displacement protein; golgi integral membrane protein 6; putative protein product of Nbla10317 |
UniProt Protein Name: | Homeobox protein cut-like 1 |
UniProt Synonym Protein Names: | CCAAT displacement protein; CDP; Homeobox protein cux-1 |
Protein Family: | Homeobox protein |
UniProt Gene Name: | CUX1 |
UniProt Entry Name: | CUX1_HUMAN |