CTSK Antibody, FITC conjugated (PACO33574)
- SKU:
- PACO33574
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | CTSK Antibody, FITC conjugated (PACO33574) |
抗体コード: | PACO33574 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cathepsin K protein (115-329AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid, pH. May play an important role in extracellular matrix degradation. |
シノニム: | Cathepsin K (EC 3.4.22.38) (Cathepsin O) (Cathepsin O2) (Cathepsin X), CTSK, CTSO CTSO2 |
UniProt Protein Function: | CTSK: Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Defects in CTSK are the cause of pycnodysostosis (PKND). PKND is an autosomal recessive osteochondrodysplasia characterized by osteosclerosis and short stature. Belongs to the peptidase C1 family. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.22.38 Chromosomal Location of Human Ortholog: 1q21 Cellular Component: extracellular region; extracellular space; lysosome Molecular Function:collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; protein binding; proteoglycan binding; serine-type endopeptidase activity Biological Process: collagen catabolic process; extracellular matrix disassembly; proteolysis; proteolysis involved in cellular protein catabolic process; toll-like receptor signaling pathway Disease: Pycnodysostosis |
NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013] |
UniProt Code: | P43235 |
NCBI GenInfo Identifier: | 1168793 |
NCBI Gene ID: | 1513 |
NCBI Accession: | P43235.1 |
UniProt Secondary Accession: | P43235,Q6FHS6, |
UniProt Related Accession: | P43235 |
Molecular Weight: | 36,966 Da |
NCBI Full Name: | Cathepsin K |
NCBI Synonym Full Names: | cathepsin K |
NCBI Official Symbol: | CTSK |
NCBI Official Synonym Symbols: | CTSO; PKND; PYCD; CTS02; CTSO1; CTSO2 |
NCBI Protein Information: | cathepsin K |
UniProt Protein Name: | Cathepsin K |
UniProt Synonym Protein Names: | Cathepsin O; Cathepsin O2; Cathepsin X |
Protein Family: | Cathepsin |
UniProt Gene Name: | CTSK |
UniProt Entry Name: | CATK_HUMAN |