CTSF Antibody (PACO33580)
- SKU:
- PACO33580
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CTSF Antibody (PACO33580) |
抗体コード: | PACO33580 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Cathepsin F protein (273-484AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. |
シノニム: | Cathepsin F (CATSF) (EC 3.4.22.41), CTSF |
UniProt Protein Function: | CTSF: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. Belongs to the peptidase C1 family. |
UniProt Protein Details: | Protein type:EC 3.4.22.41; Protease Chromosomal Location of Human Ortholog: 11q13 Cellular Component: extracellular space; lysosomal lumen; lysosome Molecular Function:cysteine-type endopeptidase activity Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis; proteolysis involved in cellular protein catabolic process Disease: Ceroid Lipofuscinosis, Neuronal, 13 |
NCBI Summary: | Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9UBX1 |
NCBI GenInfo Identifier: | 12643325 |
NCBI Gene ID: | 8722 |
NCBI Accession: | Q9UBX1.1 |
UniProt Secondary Accession: | Q9UBX1,O95240, Q9NSU4, Q9UKQ5, B2R964, |
UniProt Related Accession: | Q9UBX1 |
Molecular Weight: | 53,366 Da |
NCBI Full Name: | Cathepsin F |
NCBI Synonym Full Names: | cathepsin F |
NCBI Official Symbol: | CTSF |
NCBI Official Synonym Symbols: | CATSF; CLN13 |
NCBI Protein Information: | cathepsin F |
UniProt Protein Name: | Cathepsin F |
Protein Family: | Cathepsin |
UniProt Gene Name: | CTSF |
UniProt Entry Name: | CATF_HUMAN |