UniProt Protein Function: | GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Cytokine Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: extracellular space; extracellular region Molecular Function:protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication |
NCBI Summary: | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008] |
UniProt Code: | P04141 |
NCBI GenInfo Identifier: | 117561 |
NCBI Gene ID: | 1437 |
NCBI Accession: | P04141.1 |
UniProt Secondary Accession: | P04141,Q14CE8, Q2VPI8, Q8NFI6, |
UniProt Related Accession: | P04141 |
Molecular Weight: | 16,295 Da |
NCBI Full Name: | Granulocyte-macrophage colony-stimulating factor |
NCBI Synonym Full Names: | colony stimulating factor 2 (granulocyte-macrophage) |
NCBI Official Symbol: | CSF2 |
NCBI Official Synonym Symbols: | GMCSF |
NCBI Protein Information: | granulocyte-macrophage colony-stimulating factor; CSF; molgramostin; sargramostim |
UniProt Protein Name: | Granulocyte-macrophage colony-stimulating factor |
UniProt Synonym Protein Names: | Colony-stimulating factor; CSF; Molgramostin; Sargramostim |
Protein Family: | Granulocyte-macrophage colony-stimulating factor |
UniProt Gene Name: | CSF2 |
UniProt Entry Name: | CSF2_HUMAN |