CRTC1 Antibody, Biotin conjugated (PACO50697)
- SKU:
- PACO50697
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CRTC1 Antibody, Biotin conjugated (PACO50697) |
抗体コード: | PACO50697 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human CREB-regulated transcription coactivator 1 protein (1-248AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1α and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
シノニム: | CREB-regulated transcription coactivator 1 (Mucoepidermoid carcinoma translocated protein 1) (Transducer of regulated cAMP response element-binding protein 1) (TORC-1) (Transducer of CREB protein 1), CRTC1, KIAA0616 MECT1 TORC1 WAMTP1 |
UniProt Protein Function: | TORC1: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). In the hippocampus, involved in late-phase long- term potentiation (L-LTP) maintenance at the Schaffer collateral- CA1 synapses. May be required for dendritic growth of developing cortical neurons. Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax. Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney. Belongs to the TORC family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; nucleus Molecular Function:protein binding; cAMP response element binding protein binding Biological Process: viral reproduction; transcription, DNA-dependent; membrane hyperpolarization; rhythmic process; activation of CREB transcription factor; positive regulation of transcription from RNA polymerase II promoter; memory; protein homotetramerization; entrainment of circadian clock by photoperiod |
UniProt Code: | Q6UUV9 |
NCBI GenInfo Identifier: | 68565585 |
NCBI Gene ID: | 23373 |
NCBI Accession: | Q6UUV9.2 |
UniProt Related Accession: | Q6UUV9 |
Molecular Weight: | 62kDa; 67kDa; 68kDa |
NCBI Full Name: | CREB-regulated transcription coactivator 1 |
NCBI Synonym Full Names: | CREB regulated transcription coactivator 1 |
NCBI Official Symbol: | CRTC1 |
NCBI Official Synonym Symbols: | MAML2; MECT1; Mam-2; TORC1; TORC-1; WAMTP1 |
NCBI Protein Information: | CREB-regulated transcription coactivator 1 |
UniProt Protein Name: | CREB-regulated transcription coactivator 1 |
UniProt Synonym Protein Names: | Mucoepidermoid carcinoma translocated protein 1; Transducer of regulated cAMP response element-binding protein 1; TORC-1; Transducer of CREB protein 1 |
Protein Family: | CREB-regulated transcription coactivator |
UniProt Gene Name: | CRTC1 |
UniProt Entry Name: | CRTC1_HUMAN |