CRKL Antibody (PACO19514)
- SKU:
- PACO19514
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CRKL Antibody (PACO19514) |
抗体コード: | PACO19514 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human CRKL |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19514(CRKL Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Lovo cells, A431 cells, A549 cells, hela cells, hepG2 cells, Raji cells, mouse brain tissue, Primary antibody: PACO19514(CRKL Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO19514(CRKL Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. |
シノニム: | v-crk avian sarcoma virus CT10 oncogene homolog-like |
UniProt Protein Function: | CRKL: an oncogenic adaptor protein with an SH2-SH3-SH3 domain structure. Plays a specific role in integrin-induced migration as a downstream mediator of Src. Activates the RAS and Jnk signaling pathways. Transforms fibroblasts in a RAS-dependent fashion. A substrate of BCR-ABL and plays a role in fibroblast transformation by BCR-ABL. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: cytosol; endosome Molecular Function:protein binding; SH3/SH2 adaptor activity; signal transducer activity Biological Process: activation of MAPKK activity; JNK cascade; positive regulation of cell proliferation; Ras protein signal transduction |
NCBI Summary: | This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009] |
UniProt Code: | P46109 |
NCBI GenInfo Identifier: | 1169094 |
NCBI Gene ID: | 1399 |
NCBI Accession: | P46109.1 |
UniProt Secondary Accession: | P46109,A8KA44, D3DX35, |
UniProt Related Accession: | P46109 |
Molecular Weight: | 33,777 Da |
NCBI Full Name: | Crk-like protein |
NCBI Synonym Full Names: | CRK like proto-oncogene, adaptor protein |
NCBI Official Symbol: | CRKL |
NCBI Protein Information: | crk-like protein |
UniProt Protein Name: | Crk-like protein |
Protein Family: | Crk-like protein |
UniProt Gene Name: | CRKL |
UniProt Entry Name: | CRKL_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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