CRHR1 Antibody, Biotin conjugated (PACO25936)
- SKU:
- PACO25936
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CRHR1 Antibody, Biotin conjugated (PACO25936) |
抗体コード: | PACO25936 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Corticotropin-releasing factor receptor 1 protein (24-121AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. |
シノニム: | Corticotropin-releasing factor receptor 1 (CRF-R-1) (CRF-R1) (CRFR-1) (Corticotropin-releasing hormone receptor 1) (CRH-R-1) (CRH-R1), CRHR1, CRFR CRFR1 CRHR |
UniProt Protein Function: | CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2 Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane Molecular Function:corticotrophin-releasing factor receptor activity; protein binding Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; immune response; parturition |
NCBI Summary: | This locus represents naturally occurring readthrough transcription between neighboring GeneID:401884 (ADP-ribosylation factor 3 pseudogene) and GeneID:1394 (CRHR1, corticotropin releasing hormone receptor 1) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P34998 |
NCBI GenInfo Identifier: | 461836 |
NCBI Gene ID: | 104909134 |
NCBI Accession: | P34998.1 |
UniProt Secondary Accession: | P34998,Q13008, Q4QRJ1, Q9UK64, B4DIE9, |
Molecular Weight: | 28,122 Da |
NCBI Full Name: | Corticotropin-releasing factor receptor 1 |
NCBI Official Symbol: | MGC57346-CRHR1 |
NCBI Protein Information: | MGC57346-CRHR1 protein |
UniProt Protein Name: | Corticotropin-releasing factor receptor 1 |
UniProt Synonym Protein Names: | Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1 |
Protein Family: | Corticotropin-releasing factor receptor |
UniProt Gene Name: | CRHR1 |
UniProt Entry Name: | CRFR1_HUMAN |