CREM Antibody, Biotin conjugated (PACO55441)
- SKU:
- PACO55441
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | CREM Antibody, Biotin conjugated (PACO55441) |
抗体コード: | PACO55441 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human cAMP-responsive element modulator protein (145-321AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation. |
シノニム: | cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER), CREM |
UniProt Protein Function: | CREM: a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. An important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative splice isoforms allow this protein to exert spatial and temporal specificity to cAMP responsiveness. Twentyeight alternatively spliced isoforms of the human protein have been described, with some of them functioning as activators and some as repressors of transcription. |
UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 10p11.21 Cellular Component: transcription factor complex; cytoplasm; nucleus Molecular Function:protein binding; DNA binding; cAMP response element binding protein binding; transcription factor activity Biological Process: response to cAMP; transcription, DNA-dependent; regulation of transcription, DNA-dependent; multicellular organismal development; spermatogenesis; glycosphingolipid metabolic process; positive regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; signal transduction; cell differentiation; negative regulation of transcription, DNA-dependent |
NCBI Summary: | This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q03060 |
NCBI GenInfo Identifier: | 259016392 |
NCBI Gene ID: | 1390 |
NCBI Accession: | Q03060.5 |
UniProt Secondary Accession: | Q03060,O75519, Q14501, A8K014, A8K3J7, A8K6A1, A8MPQ2 B4DXC1, C9J785, C9JZ10, E9PAR4, E9PHM1, |
UniProt Related Accession: | Q03060 |
Molecular Weight: | 361 |
NCBI Full Name: | cAMP-responsive element modulator |
NCBI Synonym Full Names: | cAMP responsive element modulator |
NCBI Official Symbol: | CREM |
NCBI Official Synonym Symbols: | ICER; CREM-2; hCREM-2 |
NCBI Protein Information: | cAMP-responsive element modulator; CREM 2beta-a protein; CREM 2alpha-b protein; cAMP response element modulator; inducible cAMP early repressor ICER |
UniProt Protein Name: | cAMP-responsive element modulator |
UniProt Synonym Protein Names: | Inducible cAMP early repressor; ICER |
Protein Family: | cAMP-responsive element modulator |
UniProt Gene Name: | CREM |
UniProt Entry Name: | CREM_HUMAN |