CPE Antibody (PACO08563)
- SKU:
- PACO08563
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | CPE Antibody (PACO08563) |
抗体コード: | PACO08563 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human CPE |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | carboxypeptidase E; |
UniProt Protein Function: | CPE: Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.17.10; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 4q32.3 Cellular Component: cell soma; extracellular space; Golgi apparatus; plasma membrane; secretory granule; secretory granule membrane Molecular Function:carboxypeptidase activity; cell adhesion molecule binding; metallocarboxypeptidase activity; neurexin binding; serine carboxypeptidase activity Biological Process: insulin processing; metabolic process; Wnt receptor signaling pathway |
NCBI Summary: | This gene encodes a member of the M14 family of metallocarboxypeptidases. The encoded preproprotein is proteolytically processed to generate the mature peptidase. This peripheral membrane protein cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. This protein may also function independently of its peptidase activity, as a neurotrophic factor that promotes neuronal survival, and as a sorting receptor that binds to regulated secretory pathway proteins, including prohormones. Mutations in this gene are implicated in type 2 diabetes. [provided by RefSeq, Nov 2015] |
UniProt Code: | P16870 |
NCBI GenInfo Identifier: | 115892 |
NCBI Gene ID: | 1363 |
NCBI Accession: | P16870.1 |
UniProt Secondary Accession: | P16870,Q9UIU9, A8K4N1, B3KR42, B4DFN4, D3DP33, |
UniProt Related Accession: | P16870 |
Molecular Weight: | 49,886 Da |
NCBI Full Name: | Carboxypeptidase E |
NCBI Synonym Full Names: | carboxypeptidase E |
NCBI Official Symbol: | CPE |
NCBI Official Synonym Symbols: | CPH |
NCBI Protein Information: | carboxypeptidase E |
UniProt Protein Name: | Carboxypeptidase E |
UniProt Synonym Protein Names: | Carboxypeptidase H; CPH; Enkephalin convertase; Prohormone-processing carboxypeptidase |
Protein Family: | Carboxypeptidase |
UniProt Gene Name: | CPE |
UniProt Entry Name: | CBPE_HUMAN |