UniProt Protein Function: | CORIN: Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. Defects in CORIN are the cause of pre-eclampsia/eclampsia 5 (PEE5); also known as gestational proteinuric hypertension. Preeclampsia is a pregnancy-associated disease with maternal symptoms but placental origin. Unlike most other human disorders, it impacts 2 individuals, the mother and her child, both of whom can be severely affected. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.21.-; Membrane protein, integral; Cell surface; Protease Chromosomal Location of Human Ortholog: 4p12 Cellular Component: plasma membrane Molecular Function:serine-type endopeptidase activity Biological Process: female pregnancy; peptide hormone processing; regulation of blood pressure; regulation of systemic arterial blood pressure by atrial natriuretic peptide Disease: Preeclampsia/eclampsia 5 |
NCBI Summary: | This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013] |
UniProt Code: | Q9Y5Q5 |
NCBI GenInfo Identifier: | 317373348 |
NCBI Gene ID: | 10699 |
NCBI Accession: | Q9Y5Q5.2 |
UniProt Secondary Accession: | Q9Y5Q5,Q2TBD2, Q4W5E5, Q4W5G6, Q9UHY2, B0ZBE3, |
UniProt Related Accession: | Q9Y5Q5 |
Molecular Weight: | 113,297 Da |
NCBI Full Name: | Atrial natriuretic peptide-converting enzyme |
NCBI Synonym Full Names: | corin, serine peptidase |
NCBI Official Symbol: | CORIN |
NCBI Official Synonym Symbols: | CRN; ATC2; Lrp4; PEE5; TMPRSS10 |
NCBI Protein Information: | atrial natriuretic peptide-converting enzyme |
UniProt Protein Name: | Atrial natriuretic peptide-converting enzyme |
UniProt Synonym Protein Names: | Corin; Heart-specific serine proteinase ATC2; Pro-ANP-converting enzyme; Transmembrane protease serine 10 |
Protein Family: | Atrial natriuretic peptide-converting enzyme |
UniProt Gene Name: | CORIN |
UniProt Entry Name: | CORIN_HUMAN |