COPS8 Antibody, HRP conjugated (PACO57429)
- SKU:
- PACO57429
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | COPS8 Antibody, HRP conjugated (PACO57429) |
抗体コード: | PACO57429 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human COP9 signalosome complex subunit 8 protein (150-198AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
シノニム: | COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8), COPS8, CSN8 |
UniProt Protein Function: | COPS8: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN8 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytosol; nucleoplasm; nucleus; perinuclear region of cytoplasm; signalosome Molecular Function:protein binding Biological Process: activation of NF-kappaB-inducing kinase; negative regulation of cell proliferation; nucleotide-excision repair, DNA damage recognition; protein deneddylation; transcription-coupled nucleotide-excision repair |
NCBI Summary: | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99627 |
NCBI GenInfo Identifier: | 55976572 |
NCBI Gene ID: | 10920 |
NCBI Accession: | Q99627.1 |
UniProt Secondary Accession: | Q99627,Q53QS9, A8K1H6, |
UniProt Related Accession: | Q99627 |
Molecular Weight: | 23kDa |
NCBI Full Name: | COP9 signalosome complex subunit 8 |
NCBI Synonym Full Names: | COP9 signalosome subunit 8 |
NCBI Official Symbol: | COPS8 |
NCBI Official Synonym Symbols: | COP9; CSN8; SGN8 |
NCBI Protein Information: | COP9 signalosome complex subunit 8 |
UniProt Protein Name: | COP9 signalosome complex subunit 8 |
UniProt Synonym Protein Names: | COP9 homolog; hCOP9; JAB1-containing signalosome subunit 8 |
UniProt Gene Name: | COPS8 |