COPS7A Antibody (PACO43710)
- SKU:
- PACO43710
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | COPS7A Antibody (PACO43710) |
抗体コード: | PACO43710 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC, IF |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
反応性: | Human |
免疫原: | Recombinant Human COP9 signalosome complex subunit 7a protein (1-275AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO43710 at dilution of 1:100. |
![]() | Immunofluorescent analysis of Hela cells using PACO43710 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO43710 at dilution of 1:100. |
バックグラウンド: | Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. |
シノニム: | COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a), COPS7A, CSN7A DERP10 |
UniProt Protein Function: | COPS7A: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Belongs to the CSN7/EIF3M family. CSN7 subfamily. |
UniProt Protein Details: | Protein type:Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: cytoplasm; nucleoplasm; signalosome Molecular Function:protein binding Biological Process: cullin deneddylation; nucleotide-excision repair, DNA damage recognition; transcription-coupled nucleotide-excision repair |
NCBI Summary: | This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014] |
UniProt Code: | Q9UBW8 |
NCBI GenInfo Identifier: | 55976618 |
NCBI Gene ID: | 50813 |
NCBI Accession: | Q9UBW8.1 |
UniProt Secondary Accession: | Q9UBW8,Q9NVX3, Q9UJW4, A8K9A6, |
UniProt Related Accession: | Q9UBW8 |
Molecular Weight: | 30,277 Da |
NCBI Full Name: | COP9 signalosome complex subunit 7a |
NCBI Synonym Full Names: | COP9 signalosome subunit 7A |
NCBI Official Symbol: | COPS7A |
NCBI Official Synonym Symbols: | CSN7; CSN7A; SGN7a |
NCBI Protein Information: | COP9 signalosome complex subunit 7a |
UniProt Protein Name: | COP9 signalosome complex subunit 7a |
UniProt Synonym Protein Names: | Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a |
UniProt Gene Name: | COPS7A |
UniProt Entry Name: | CSN7A_HUMAN |